Sickness behaviours—such as increased activity, disrupted sleep, and reduced feeding—are conserved responses to infection and reflect the complex crosstalk between the nervous and immune systems. Our previous work demonstrated that infection in Drosophila melanogaster elevates activity levels through both Toll-dependent and Toll-independent pathways. Building on these findings, we are now exploring how sleep interacts with immune function and infection outcomes. Using the genetic and behavioural tools available in Drosophila, we aim to dissect the molecular mechanisms underlying sleep regulation during infection and identify the immune signals involved in modulating behaviour. In parallel, our laboratory leverages the Drosophila model to study bacterial physiology and genetics in the context of infection, in close collaboration with members of the SAMIGE scientific community. These integrative approaches position Drosophila as a powerful system to understand how the immune response affects host behaviour and how behavioural states may, in turn, shape infection dynamics.